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Diabetes Connections with Stacey Simms Type 1 Diabetes

The T1D news show you've been waiting for! Long-time broadcaster, blogger and diabetes mom Stacey Simms interviews prominent advocates, authors and speakers. Stacey asks hard questions of healthcare companies and tech developers and brings on "everyday' people living with type 1. Great for parents of T1D kids, adults with type 1 and anyone who loves a person with diabetes.
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Now displaying: 2022
Sep 9, 2022

It’s in the news! The top stories and headlines around the diabetes community this week include: A new way to sneak islet cells into the body without needing immunosuppressive drugs, routinely checking young children for T1D markets before symptoms show up, a non invasive way to measure blood glucose uses Radio Frequency, a DIY movement publishes in the New England Journal of Medicine and more!

Check out Stacey's book: The World's Worst Diabetes Mom!

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Episode Transcription Below (or coming soon!)

Please visit our Sponsors & Partners - they help make the show possible!

*Click here to learn more about OMNIPOD*

*Click here to learn more about AFREZZA*

*Click here to learn more about DEXCOM*

Hello and welcome to Diabetes Connections In the News! I’m Stacey Simms and these are the top diabetes stories and headlines of the past seven days.
XX
In the news is brought to you by T1D Exchange! T1D Exchange is a nonprofit organization dedicated to improving outcomes for the entire T1D population.
https://t1dexchange.org/stacey/
XX
French biopharma company Adocia has established a first proof of concept for its AdoShell Islets implant. This was in rats.. but they achieved glycemic control without insulin injections and without immunosuppressive drugs for four months.
AdoShell Islets is an immuno-protective synthetic biomaterial that secrets insulin in response to blood glucose levels. The physical barrier formed by the AdoShell biomaterial allows the implanted cells to be invisible to the host’s immune system while allowing the necessary physiological exchanges to occur for the survival and function of the islets.
These researchers are optimistic that their unique approach can be translated from one species to another.
https://www.labiotech.eu/trends-news/adocia-implants-diabetes/
XX
Can starting a closed loop system right away help keep kids with type 1 in the honeymoon stage longer? New study says.. probably not.
The latest findings are from the Closed Loop From Onset in Type 1 Diabetes (CLOuD) trial, a multicenter, open-label, parallel-group, randomized study, published online September 7 in the New England Journal of Medicine by Charlotte K. Boughton, PhD, and colleagues.
In CLOuD, 97 youths aged 10-17 years were randomized to hybrid closed-loop therapy or standard insulin therapy (control) within 21 days of type 1 diabetes diagnosis. I found this a bit confusing, in the standard insulin therapy groups, participants could switch to insulin pump therapy or use flash or continuous glucose monitoring (CGM) or approved closed-loop systems if clinically indicated. So this isn’t comparing an AID system to MDI.
At 12 months, there were no differences after a mixed-meal tolerance test, with levels declining in both groups and dropping further by 24 months. Interestingly, they said glycemic control didn’t differ significantly between the two groups.

https://www.medscape.com/viewarticle/980356
XX
Moving closer to a non-invasive way to measure blood glucose. The GlucoRx BioXensor uses radio frequency technology alongside a multiple sensor approach to measure blood glucose levels every minute. This looks to be about the size of a Libre 3 or Dexcom G7..
It’s said to have smart alarms and remote monitoring capability and just sticks on the skin. The MARD is 10 point 4, which is less accurate than CGMs on the market now, but much better than any other noninvasive device to make it this far. In addition to measuring blood glucose the makers say it can measure oxygen levels, ECG, respiration rate, heart rate, temperature, activity, sleep, and early fall detection.
Pivotal clinical study later this year and then the say they’ll submit for European approval.
https://www.med-technews.com/news/latest-medtech-news/glucorx-and-cardiff-university-to-bring-out-non-invasive-con/
XX
RESEARCHERS in Oxford have launched the first UK study in the general population to test for early markers of type 1 diabetes, before children develop symptoms or need insulin. They’re offering a finger stick test when children have their pre-school vaccination. Very small start, only 60 kids, but these researchers say with a recent, more accurate test to check for markers early on, they hope to find more children before DKA sets in.
https://www.oxfordmail.co.uk/news/20977659.oxford-scientists-launch-study-early-markers-type-1-diabetes-children/
XX
The first Randomized Controlled Trial on open source automated insulin delivery (AID) is now published in a peer-reviewed medical journal. Big news for and from the we are not waiting crowd.
The CREATE Trial evaluated the efficacy and safety of an open-source system using the OpenAPS algorithm in a modified version of AndroidAPS. This study included children and adults and found that across all ages, time in range was 14 percent higher than those who used commercial hybrid closed loop systems. There’s more to it, and I”ll link it up, but this study concluded that a widely used open-source AID solution, works and is safe. Congrats to Dana Lewis and all the researchers involved.
https://diyps.org/2022/09/07/nejm-publishes-rct-on-open-source-automated-insulin-delivery-openaps-algorithm-in-androidaps-in-the-create-trial/
XX
Back to the news in a moment but first..
The T1D Exchange Registry is a research study conducted online over time, designed to foster innovation and improve the lives of people with T1D. The platform is open to both adults and children with T1D living in the U.S. Personal information remains confidential and participation is fully voluntary. Once enrolled, participants will complete annual surveys and have the opportunity to sign up for other studies on specific topics related to T1D. The registry aims to improve knowledge of T1D, accelerate the discovery and development of new treatments and technologies, and generate evidence to support policy or insurance changes that help the T1D community. By sharing opinions, experiences and data, patients can help advance meaningful T1D treatment, care and policy.
The registry is now available on the T1D Exchange website and is simple to navigate, mobile and user-friendly. For more information or to register, go to www.t1dregistry.org/stacey
XX

Medtronic is waiting for FDA clearing of the new 780G.. already approved in Europe. New study results published in The Lancet Diabetes & Endocrinology, Medtronic announced Thursday put the AID pump up against multiple daily injections plus CGM. Small study, 82 people, all with an A1C over 8. After using the 780G for six months, the group saw a reduction of 1.4 percent in their levels with a quarter of that group dropping their A1C below 7. None of the MDI group dropped to that level. Time in range saw most improvement overnight.
The MiniMed 780G system has been cleared in Europe since 2020. Medtronic submitted it to the FDA for U.S. approval in the spring of 2021 but is still awaiting a decision, slowed down by the roadblocks caused by a late 2021 warning letter from the agency that called out quality control issues at the California headquarters of its diabetes business.
https://www.fiercebiotech.com/medtech/medtronics-new-minimed-insulin-pump-adds-27-boost-time-range-study-finds
XX
Change at one of the top posts at Dexcom. Jake Leach moves from Chief Technology Officer to Chief operating officer. He’s been at the company since 2004 to work on the first commercial Dexcom CGM system. He’s been a frequent guest of the show and we hope that continues.
https://www.businesswire.com/news/home/20220831005236/en/DexCom-Promotes-Jake-Leach-to-Chief-Operating-Officer
XX
Next week we’re looking ahead to the New York City Marthong. Beyond Type 1 puts together a gret team each year and I’m taking to one of the runners. He’s also nabbed a spot in the world series of poker – which do you think is tougher on his type 1 diabetes? This past episode is all about Omnipod 5 – a panel of people who’ve sued it for a few weeks now.. and the director of medical affairs to answer your questions.
Listen wherever you get your podcasts
That’s In the News for this week.. if you like it, please share it! Thanks for joining me! See you back here soon.

Sep 6, 2022

Omnipod 5 was approved earlier this year and just rolled out to a wider release. So how is the first tubeless automated insulin delivery system doing in the real world? We put together a panel of early adopters and got their feedback. That was great, but it brought up quite a few questions, so we reached out to Omnipod for clarification and follow up. The result is a super-sized episode full of info!

Our panel: Liat Kochavi, mother an almost-8-year-old with T1D, Stephanie Williams, mother of a teen with type 1, and Sam Durante who was diagnosed with type 1 just before she turned 16. You'll also here from Insulet's Director of Medical Affairs Alex Nyugen, RD, CDCES.

FYI, we were fortunate to speak with Insulet earlier this year, just after the FDA approval, and really went point by point through Omnipod 5. So we’re not rehashing everything here. If you missed that episode, here's the link: Omnipod 5 interview from Feb 2022

Check out Stacey's book: The World's Worst Diabetes Mom!

Join the Diabetes Connections Facebook Group!

Sign up for our newsletter here

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Episode Transcription Below (or coming soon!)

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Sep 2, 2022

It’s in the news! The top stories and headlines around the diabetes community this week include new progress in the quest for oral insulin to treat type 1, a new study says a common type 2 diabetes drug may help those with serious heart condition, a look at teen brains and T1D, NSAID and type 2 and more!

Learn about the T1d Exchange: www.t1dexchange.org/stacey 

Check out Stacey's book: The World's Worst Diabetes Mom!

Join the Diabetes Connections Facebook Group!

Sign up for our newsletter here

-----

Use this link to get one free download and one free month of Audible, available to Diabetes Connections listeners!
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Episode Transcription Below (or coming soon!)

Please visit our Sponsors & Partners - they help make the show possible!

*Click here to learn more about OMNIPOD*

*Click here to learn more about AFREZZA*

*Click here to learn more about DEXCOM*

Hello and welcome to Diabetes Connections In the News! I’m Stacey Simms and these are the top diabetes stories and headlines of the past seven days.
XX
In the news is brought to you by T1D Exchange! T1D Exchange is a nonprofit organization dedicated to improving outcomes for the entire T1D population.
https://t1dexchange.org/stacey/
XX
Our top story.. very early on here, but some progress in oral insulin for type 1. A team at University of British Columbia has developed a different kind of tablet that isn't made for swallowing, but instead dissolves when placed between the gum and cheek. This method delivered all the insulin to the liver without wasting or decomposing any insulin along the way. That’s a big change from earlier studies and methods. The oral tablets absorb after about half an hour and last for up to four hours.. long way to go, no human trials yet. The the lead researcher on this project has a father with type 1 .
https://www.sciencedaily.com/releases/2022/08/220830093215.htm?fbclid=IwAR1AzjI5UJma9I6g4hST044FS0MbJnUA0EXCmKXyhcOiOKL-ckIQTO4h8dY
XX
The type 2 diabetes drug dapagliflozin might also be used to help people with heart failure. A new study at Brigham and Women's Hospital showed that dapagliflozin – sold under the brand name Farxiga - reduced the risk of a cardiovascular death, or worsening heart failure, regardless of ejection fraction. Ejection fraction is a term that basically refers to how much blood is pumped out by the left ventricle of the heart each time it contracts. That’s important because this drug has already been shown to help people who have the reduced pumping. And that’s a lot more people. Big study here, more than 12-thousand people with lots of ages and races, benefits consistent throughout.
https://www.bostonglobe.com/2022/08/29/business/brigham-womens-researchers-say-diabetes-drug-helps-reduce-heart-failure/
XX
I hesitate to bring this study up, but it’s gotten a lot of attention this week. It shows tight control of blood sugar in teens with Type 1 diabetes may help reduce the disease’s damaging effects on the brain. But this small study from Nemours Children’s Health, Jacksonville and Stanford University School of Medicine didn’t release any numbers, n other words, it’s not clear what they mean by tight control or at what level they’re referring to for brain issues. Their findings to indicate that automated hybrid closed loop systems work really well and that better glucose control can actually improve brain structure and function in teens with type 1. I’ve reached out to this group and we’re working on getting more information in a future episode.
https://neurosciencenews.com/blood-sugar-brain-diabetes-21328/
XX
Very early on here.. but an Indiana startup says they have a potentially game changing type 1 drug in development. In T1D, the body’s immune system causes destruction of beta cells, and as a result, they eventually stop producing insulin. These researchers say their models show thy can take what were thought to be dead beta cells, which are actually sleeping beta cells, and increase their insulin secretion and, basically, get them back to a functional state.” They’re focusing on a calcium imbalance within the beta cell and designing molecules to correct that calcium imbalance, ultimately returning the pancreas to a healthy state. JDRF has given them a big grant for a two year project, hopefully getting them to clinical trials.
https://www.insideindianabusiness.com/articles/startup-awarded-nearly-1m-to-advance-diabetes-drug
XX
People with type 2 diabetes might face a substantially increased risk of heart failure if they take ibuprofen or some other type of nonsteroidal anti-inflammatory drug (NSAID), accord to a new Danish study.
Short-term NSAID use increased risk of hospitalization for heart failure by 43% in people with type 2 but no previous heart problems. This was a large but preliminary study presented at the European Society of Cardiology's annual meeting. NSAIDs increased the risk of heart failure even more in type 2 diabetics who were 80 or older (78%) or who had high blood sugar levels (68%), the results showed. Those who'd never used an NSAID before had the worst reaction, with their heart failure risk nearly tripling. Type 2 diabetics should consult with their doctor before taking any pain medicine, the doctors said. Other types of pain meds -- specifically acetaminophen (Tylenol) -- should be safe for them to use.
https://www.usnews.com/news/health-news/articles/2022-08-24/certain-painkillers-raise-heart-failure-risk-in-people-with-type-2-diabetes

XX
Back to the news in a moment but first..
The T1D Exchange Registry is a research study conducted online over time, designed to foster innovation and improve the lives of people with T1D. The platform is open to both adults and children with T1D living in the U.S. Personal information remains confidential and participation is fully voluntary. Once enrolled, participants will complete annual surveys and have the opportunity to sign up for other studies on specific topics related to T1D. The registry aims to improve knowledge of T1D, accelerate the discovery and development of new treatments and technologies, and generate evidence to support policy or insurance changes that help the T1D community. By sharing opinions, experiences and data, patients can help advance meaningful T1D treatment, care and policy.
The registry is now available on the T1D Exchange website and is simple to navigate, mobile and user-friendly. For more information or to register, go to www.t1dregistry.org/stacey
XX
We told you about The Human Trial, Watch this gripping new documentary about the brave men and women who volunteer to test a radical new treatment for type 1 diabetes. n 2011, Lisa Hepner and her husband Guy Mossman heard about a radical stem cell treatment for diabetes, a disease that shockingly kills more than five million people each year. Driven by a desire to cure Lisa of her own type 1 diabetes (T1D), the filmmakers were given unprecedented, real-time access to a clinical trial — only the sixth-ever embryonic stem cell trial in the world. What follows is an intimate journey with the patients and scientists who put themselves on the line to be first.
Now, in partnership with Beyond Type 1 & JDRF , they’re offering the film for free. You are urged to make a donation to JDRF when you click over, there is an option to select zero,
https://watch.showandtell.film/watch/the-human-trial-beyond-type-1
XX
Next week we’ve got a great episode all about Omnipod 5 in the real world. I spoke to a panel of moms and a young adult using the system. And we’ve got Insulet’s Director of Medical affairs addressing the questions that come up. This past episode is with my son Benny, talking about what it was like to spend 8 weeks away at non diabetes camp without any remote monitoring from us.
Listen wherever you get your podcasts
That’s In the News for this week.. if you like it, please share it! Thanks for joining me! See you back here soon.

Aug 30, 2022

Stacey's son spent the summer away at regular, non-diabetes sleepaway camp. 8 weeks managing all of his own care, with no remote monitoring. You had a lot of questions, including how he manages overnight lows:

Benny is 17, he was diagnosed just before he turned two and, as usual, he has a lot to say. He had quite a few adventures at camp, but everything turned out okay. We get his take on independence, responsibility and a glimpse into how a teen with type 1 thinks.

This podcast is not intended as medical advice. If you have those kinds of questions, please contact your health care provider.

Check out Stacey's book: The World's Worst Diabetes Mom!

Join the Diabetes Connections Facebook Group!

Sign up for our newsletter here

-----

Use this link to get one free download and one free month of Audible, available to Diabetes Connections listeners!
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Episode Transcription Below (or coming soon!)

Please visit our Sponsors & Partners - they help make the show possible!

*Click here to learn more about OMNIPOD*

*Click here to learn more about AFREZZA*

*Click here to learn more about DEXCOM*

Aug 26, 2022

It’s in the news! The top stories and headlines around the diabetes community this week include a new attempt to have fewer misdiagnoses of type 2 (when it's really type 1) diabetes, a new approval for Omnipod 5 down to two years old, a look at the endocrinologist shortage in the US, a milestone for Tandem and more!

Check out Stacey's book: The World's Worst Diabetes Mom!

Join the Diabetes Connections Facebook Group!

Sign up for our newsletter here

-----

Use this link to get one free download and one free month of Audible, available to Diabetes Connections listeners!
-----

Episode Transcription Below (or coming soon!)

Please visit our Sponsors & Partners - they help make the show possible!

*Click here to learn more about OMNIPOD*

*Click here to learn more about AFREZZA*

*Click here to learn more about DEXCOM*

Hello and welcome to Diabetes Connections In the News! I’m Stacey Simms and these are the top diabetes stories and headlines of the past seven days.
XX
In the news is brought to you by T1D Exchange! T1D Exchange is a nonprofit organization dedicated to improving outcomes for the entire T1D population.
https://t1dexchange.org/stacey/
XX
New effort to avoid the very common misdiagnosis of type 2 when it’s actually type 1. JDRF and a a company called IQVIA are seeing if artificial intelligence can be used here. IQVIA used machine learning to look at data from individuals diagnosed with T2D and then, later, diagnosed with T1D within a specific time frame. The big problem, the company says, is that medical records are often incomplete and are compiled using different standards and formats. They call it a good starting point though. Earlier studies have shown that possibly 40-percent of adults with new onset type 1 are first misdiagnosed with type 2.
https://www.jdrf.org/blog/2022/08/11/iqvia-algorithm-for-misdiagnoses/

XX
New UK study about COVID, diabetes and kids.. shows there was an increase in new cases and in DKA. This was from March 2020 to February of 2021, compared to same time the previous year. This was a large study, looking back at cases across 49 sites.
There was a 17% increase in new-onset diabetes from Year 1 to Year 2, mostly of type 1 diabetes. ED visits for DKA dropped by 31.9% during the pandemic year among patients with existing diabetes. There was a 43% increase in severity of new-onset disease from Year 1 to Year 2, with severe DKA increasing by 79% (P < .001) and intensive care admissions by 89% (P < .05 There were limitations to this study, the biggest is that data was only captured for those who went to the emergency room. The question of whether SARS-CoV-2 can trigger new-onset diabetes remains unanswered.

https://www.medscape.com/viewarticle/979381#:~:text=There%20was%20a%2017%25%20increase,by%2079%25%20(P%20%3C%20.
XX
Omipod 5 is now FDA approved for kids as young as two.
Omnipod 5, the first tubeless automated insulin delivery (AID) system in the U.S., was originally cleared for use in individuals aged six and older in January 2022. That makes Omnipod 5 the only AID approved for the toddler set. Tandem’s Control IQ ia approved down to age 6 and Medtronic 780G down to age 7
https://www.businesswire.com/news/home/20220822005158/en/Insulet-Announces-FDA-Clearance-of-Omnipod%C2%AE-5-for-Children-Aged-Two-Years-and-Older-with-Type-1-Diabetes
XX
Milestone from Tandem they say that in the first month since the new mobile bolus feature was released, users have delivered more than 1 million insulin boluses. The company said in a news release that it is the first-ever FDA-cleared smartphone application capable of initiating insulin delivery on both iOS and Android operating systems. The company added that it is now available on approximately 30 different devices.

https://www.drugdeliverybusiness.com/tandem-diabetes-app-insulin-bolus-million/

XX
What looks like an editorial in a publication called Stability Health caught my eye. It’s all about the shortage of endocrinologists in the US. Right now there are only 8-thousand in practice across the whole country.
Endocrinologists receive the lowest compensation of all internal medicine (IM) specialties — lower even than practicing general internists — and 76–89% of medical students graduate with astronomical debt.
Additionally, these clinicians often make themselves available outside of their office hours. But since this time may not be billable, it is often not supported in salaried compensation.
Separately (but related), in 2016, 71% of entrants to the field of endocrinology were female. Due to America’s long-standing gender wage gap, this may be a contributing factor in wage stagnation.
Roughly 85% of Americans with diabetes rely on a general practitioner for their care. I’ll link up the column so you can take a look.
https://stabilityhealth.com/endocrinologist-shortage/?fbclid=IwAR0jx-nSiOL2UccmoJ9H74SnC6l3M5CCppecGcQ2t2M_zc7U-ydOj4JxfQ4#:~:text=Today%2C%2034.2%20million%20Americans%20are,currently%20practice%20in%20the%20U.S
XX
Update on one of the CGM smartwatches we’ve been keeping an eye on.. the K-Watch Glucose CGM watch is being tested by a French Company. They had their first clinical trials last year and got results this summer. the first run had a MARD of 29-percent.. brought down to a much better 16-percent. MARD is of course Mean Absolute Relative Difference to a calibrated meter and the gold standard right now is under 10 with Dexcom and Libre’s next offerings closer to 8.. so a way to go here.
https://www.notebookcheck.net/Painless-K-Watch-Glucose-blood-free-CGM-smartwatch-produces-positive-first-in-human-trial-results-as-PKvitality-targets-2024-for-availability.642380.0.html
XX
Back to the news in a moment but first..
The T1D Exchange Registry is a research study conducted online over time, designed to foster innovation and improve the lives of people with T1D. The platform is open to both adults and children with T1D living in the U.S. Personal information remains confidential and participation is fully voluntary. Once enrolled, participants will complete annual surveys and have the opportunity to sign up for other studies on specific topics related to T1D. The registry aims to improve knowledge of T1D, accelerate the discovery and development of new treatments and technologies, and generate evidence to support policy or insurance changes that help the T1D community. By sharing opinions, experiences and data, patients can help advance meaningful T1D treatment, care and policy.
The registry is now available on the T1D Exchange website and is simple to navigate, mobile and user-friendly. For more information or to register, go to www.t1dregistry.org/stacey
XX
Association of Diabetes Care and Education Specialists gave their lifetime Achievement Award to Dr. Kenneth Moritsugu, former surgeon general of the United States. Many of you may know him as the Chairman of the Board of Children with Diabetes you see him at Friends for Life and other events. He’s been involved with lot of national diabetes groups and effort – he was diagnosed with LADA at age 55. He’s also been a guest of this show.. so congrats Dr. Moritsugu.
https://www.healio.com/news/endocrinology/20220814/a-lifetime-of-service-a-conversation-with-kenneth-moritsugu-md-mph-facpm-faade?fbclid=IwAR2DyFSAyxCqeGMpmGHAi1FG1swihxFAPe-WveCaCP6NJrcUd0rFioBedQU
XX
Next week we’re talking back to school! The wonderful diabetes educator Anna Sabino from Finding Smiles coaching will join me to talk 504, remote monitoring, supplies and lots more. The long format episode out right now is with Patients For Affordable Drugs about the bill that passed the Senate this week. The insulin copay cap was removed, but what does it really mean for medication prices?
Listen wherever you get your podcasts
That’s In the News for this week.. if you like it, please share it! Thanks for joining me! See you back here soon.

Aug 23, 2022

Back to school can be one of the most stressful times for parents of kids with T1D and it’s okay to admit that. This week, Anna Sabino, of Finding Smiles Coaching, a diabetes educator who lives with type 1, joins Stacey to help you out! We’re going to go through 504s, school supplies, remote monitoring, last minute issues and set you up for long term success.

This podcast is not intended as medical advice. If you have those kinds of questions, please contact your health care provider.

More about Anna, including a great special she has for parents and families right now: https://www.findingsmilescoaching.com/

ADA Safe at School: https://diabetes.org/tools-support/know-your-rights/safe-at-school-state-laws

504 plan examples: https://diabetes.org/tools-support/know-your-rights/safe-at-school-state-laws/written-care-plans/section-504-plan

Check out Stacey's book: The World's Worst Diabetes Mom!

Join the Diabetes Connections Facebook Group!

Sign up for our newsletter here

-----

Use this link to get one free download and one free month of Audible, available to Diabetes Connections listeners!
-----

Episode Transcription Below (or coming soon!)

Please visit our Sponsors & Partners - they help make the show possible!

*Click here to learn more about OMNIPOD*

*Click here to learn more about AFREZZA*

*Click here to learn more about DEXCOM*

Aug 19, 2022

It's in the news! The top stories and headlines around the diabetes community this week include: People on Medicare should see insulin prices capped, A look at whether the tuberculosis vaccine prevented Covid in people with type 1 diabetes, Tandem's CEO has some news about their tiny Mobi pump, students create non-invasive glucose monitoring, and some progress on smart insulin.

Learn more about the T1D Exchange: https://t1dexchange.org/stacey/

Check out Stacey's book: The World's Worst Diabetes Mom!

Join the Diabetes Connections Facebook Group!

Sign up for our newsletter here

-----

Use this link to get one free download and one free month of Audible, available to Diabetes Connections listeners!
-----

Episode Transcription Below (or coming soon!)

Please visit our Sponsors & Partners - they help make the show possible!

*Click here to learn more about OMNIPOD*

*Click here to learn more about AFREZZA*

*Click here to learn more about DEXCOM*

Hello and welcome to Diabetes Connections In the News! I’m Stacey Simms and these are the top diabetes stories and headlines of the past seven days.
XX
In the news is brought to you by T1D Exchange! T1D Exchange is a nonprofit organization dedicated to improving outcomes for the entire T1D population.
https://t1dexchange.org/stacey/
XX
The Inflation Reduction act is now law.. and that means a big change for Medicare patients. Among other things, it limits insulin copays to $35 per month for Medicare Part D beneficiaries starting in 2023 and caps annual out-of-pocket cap on Part D prescription drugs at 2-thousand dollars starting in 2025. Medicare will also now have the ability to negotiate the costs of certain prescription drugs. Democrats say they will try to bring a stand alone proposal to ap the price of insulin for a broader population this fall.
XXDid the Tuberculosis vaccine protect people with type 1 from Covid and other infectious diseases? Researchers at Harvard Medical School and Massachusetts General Hospital have published a new paper looking at the BCG or tuberculosis vaccine. In a double-blind, placebo-controlled study of patients with type 1 diabetes conducted at the start of the pandemic, before COVID vaccines were available, only 12.5 percent of placebo-treated individuals and 1 percent of BCG-treated individuals had confirmed COVID-19, yielding a vaccine effectiveness of 92 percent.
The BCG-vaccinated group also displayed protective effects against other infectious diseases, including fewer symptoms, lesser severity and fewer infectious disease events per patient. No BCG-related systemic adverse events occurred.
The participants in the COVID trial had previously enrolled in a clinical trial testing the effectiveness of the BCG vaccine for type 1 diabetes. Participants in the test group had received multiple vaccinations before the onset of the pandemic in early 2020.
https://hms.harvard.edu/news/tb-drug-vs-covid

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Students at the American University in Cairo have developed a device that non-invasively measures blood glucose levels, winning first place in 2022 Johns Hopkins Healthcare Design Competition. The device uses near-infrared spectroscopy (speck-troh-sku-pee). It’s called GlucoClip and there’s also a mobile app. . The project took a year, with the team having designed a prototype and testing it on more than 100 people. Amazing that this took students less than a year.. we’ll see if the large commercial companies can accomplish getting something like this to the marketplace.
https://www.egyptindependent.com/auc-students-win-first-place-at-johns-hopkins-healthcare-design-competition-2022/
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Interesting progress on glucose-responsive insulin, also called smart insulin. These researchers envision ultra-stable proteins containing a glucagon analog “stapled” to an insulin analog. Preliminary studies are moving along at Indiana University. As the name indicates, this would be insulin that only responds when there is too much glucose in the blood, making the risk of low blood sugar much less likely. Nice to see some options may be possible, last year Lilly bought Protomer Technologies which had smart insulin in pre-clinical development.
https://diabetesresearchconnection.org/projects/fusion-protein/
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New CEO over at Beta Bionics – the company behind the iLet Bionic Pancreas, currently in front of the FDA. Sean Saint will be the new CEO, Martha Goldberg Aronson was interim, we talked to her for the podcast a few months ago, will remain on the Beta Bionics Board of Directors. Saint is an engineer, entrepreneur, diabetes technologist and innovator, and lives with type 1. He started at Medtronic and ahs also been at Dexcom and Tandem. It was after working at all those diabetes companies that he developed type 1 as an adult.. and founded Companion Medical, maker of the InPen. Really interesting story and I hope he’ll come on the podcast soon.
https://www.globenewswire.com/news-release/2022/08/15/2498485/0/en/Beta-Bionics-Appoints-Sean-Saint-as-CEO-and-Board-Member.html

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But with the troubles of the second quarter solidly in the rearview mirror, Tandem is back in optimist mode, with a rosy outlook toward sales of both existing and upcoming technologies.
Chief among the latter category is the Mobi insulin pump. The device is about half the size of Tandem’s flagship t:slim pump and can be fully controlled by a user’s smartphone. It’ll also represent “the first novel form factor launched in our space since we introduced t:slim a decade ago,” Sheridan said on the call.
“We are in the final stages of testing, as well as drafting the submission, and intend to submit a 510(k) to the FDA this quarter,” the chief executive said. He noted that Tandem is already preparing for the pint-sized pump’s commercial launch following FDA clearance, which it’s tentatively expecting to snag in the first half of 2023.
In the meantime, Sheridan said Tandem is also working closely with partners Dexcom and Abbott to integrate its insulin pumps with their newest continuous glucose monitors: Abbott’s FreeStyle Libre 3, which was cleared by the FDA just a few months ago, and Dexcom’s G7 device, whose own FDA review is still underway after an agency request for more information.
RELATED

https://www.fiercebiotech.com/medtech/tandem-lines-fda-review-new-pint-sized-insulin-pump-amid-lower-expected-sales
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Possible new way to look for type 2 diabetes before there are any severe symptoms. Researchers from the University of Geneva found that a decline in one molecule indicates a loss of functional beta cells. This molecule, which can be easily detected by a blood test, may be utilized to detect the onset of diabetes in at-risk individuals.

These researchers say this discovery opens new avenues for preventing diabetes, particularly for at-risk people. A simple blood sampling followed by an inexpensive specific test could identify a potential diabetes onset in these people, prompting actions to be taken before the situation becomes irreversible.”

https://www.techexplorist.com/molecule-identify-development-diabetes/53106/
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The T1D Exchange Registry is a research study conducted online over time, designed to foster innovation and improve the lives of people with T1D. The platform is open to both adults and children with T1D living in the U.S. Personal information remains confidential and participation is fully voluntary. Once enrolled, participants will complete annual surveys and have the opportunity to sign up for other studies on specific topics related to T1D. The registry aims to improve knowledge of T1D, accelerate the discovery and development of new treatments and technologies, and generate evidence to support policy or insurance changes that help the T1D community. By sharing opinions, experiences and data, patients can help advance meaningful T1D treatment, care and policy.
The registry is now available on the T1D Exchange website and is simple to navigate, mobile and user-friendly. For more information or to register, go to www.t1dregistry.org/stacey
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Abbott and Weight Watchers are teaming up. They’ve set up what they call a “strategic partnership” that will help people living with diabetes better understand and manage both their condition and their weight. The release says both companies are bringing their marketed products together to help patients, while also boosting their use. The partnership will start in earnest from next year and initially focus on the U.S.
https://www.fiercepharma.com/marketing/abbott-teams-weightwatchers-digital-diabetes-journey-health
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Next week we’re talking back to school! The wonderful diabetes educator Anna Sabino from Finding Smiles coaching will join me to talk 504, remote monitoring, supplies and lots more. The long format episode out right now is with Patients For Affordable Drugs about the bill that passed the Senate this week. The insulin copay cap was removed, but what does it really mean for medication prices?
Listen wherever you get your podcasts
That’s In the News for this week.. if you like it, please share it! Thanks for joining me! See you back here soon.

Aug 16, 2022

You may know the Inflation Reduction Act best for being the latest time an insulin price measure was NOT voted through. But supporters say there’s a lot here that will help patients save money, including those with diabetes.

We talk with Sarah Kaminer Bourland, Legislative Director of Patient for Affordable Drugs Now. She explains what this new plan will mean for those on and not on Medicare, debunk some of the talking points you might have heard and look ahead to what could be next for insulin pricing.

Share your story with P4AD: https://secure.everyaction.com/SvIaRhn3VEmVAkJ1ccQETA2

This podcast is not intended as medical advice. If you have those kinds of questions, please contact your health care provider.

Check out Stacey's book: The World's Worst Diabetes Mom!

Join the Diabetes Connections Facebook Group!

Sign up for our newsletter here

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Episode Transcription Below (or coming soon!)

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Aug 12, 2022

Get caught up on the news and headlines around the diabetes community! The top stories in the last seven days: Senate Republicans nixed an insulin copay cap, but Democrats say they will revisit this issue in a few weeks, Dexcom pushed back their G7 timeline in the USA after the FDA asks for changes, once weekly basal insulin moves forward in trials. Plus, Beyond Type 1 is back in the NYC Marathon and much more!

Learn more about the T1D Exchange: https://t1dexchange.org/stacey/

Check out Stacey's book: The World's Worst Diabetes Mom!

Join the Diabetes Connections Facebook Group!

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Use this link to get one free download and one free month of Audible, available to Diabetes Connections listeners!
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Episode Transcription Below (or coming soon!)

Please visit our Sponsors & Partners - they help make the show possible!

*Click here to learn more about OMNIPOD*

*Click here to learn more about AFREZZA*

*Click here to learn more about DEXCOM*

 

Hello and welcome to Diabetes Connections In the News! I’m Stacey Simms and these are the top diabetes stories and headlines of the past seven days.
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In the news is brought to you by T1D Exchange! T1D Exchange is a nonprofit organization dedicated to improving outcomes for the entire T1D population.
https://t1dexchange.org/stacey/
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The copay cap on insulin may come back before the Senate in a few weeks. Senate Majority Leader Charles Schumer say he’ll bring tht issue back up.. after Republicans blocked it in a sweeping climate, inflation and health care package passed by the Senate on Monday. Speaking on MSNBC’s “The Rachel Maddow Show.” Schumer said, “We’re going to come back and make them vote on that again.” Seven Republicans still voted with all 50 Democrats, three short of the 60 votes needed, and it is possible more Republicans would support it if it came up as a standalone measure. It’s not clear if this would again be a copay cap or in fact a cap on the actual price of insulin for all, including the uninsured.
https://thehill.com/policy/healthcare/3594003-schumer-senate-will-vote-again-on-35-insulin-cap-after-gop-blocked-it/

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Dexcom is pushing back the timeline for a U.S. launch the G7. That’s after the FDA raised questions about the device’s software during a review. This has something to do with how the G7 and it’s smartphone apps deliver alarms to users. Looks like maybe a limited release in the 4th quarter of this year and full rollout in 2023 if there aren’t any other hiccups. As you likely know, the G7 is nearly 60-percent smaller than the G6, it’s transmitter and sensor all in one and has a much shorter warmup period. It’s been approved in Europe since March.

https://www.fiercebiotech.com/medtech/dexcom-resubmit-g7-glucose-monitor-software-fda-review-pushing-back-us-launch
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One type of once-a-week basal insulin gets the go ahead to move forward with clinical trials in the US. Gan & Lee Pharmaceuticals says it’s investigation drug called GZR4 is more stable with less day to day variation than once a day basal insulin. There are a few of these weekly insulins in trials, none yet approved. Gan & Lee is also doing trials of the drug in China where they are already a big player in the insulin market.
https://www.ganlee.com/detail/668.html
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Good news for Senseonics, makers of the Eversense implantable CGM. Shares were up on second quarter earnings and future expectations. I don’t generally report on stock market moves of diabetes companies, but the past few years have been a bit iffy for Senseonics and there was speculation on whether this CGM option might not be available in the US. They partnered with Ascensia Diabetes Care and got the six month approval for Eversense earlier this year.
https://www.massdevice.com/senseonics-stock-q2-2022/
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A new call for comments to the FDA but the deadline is TODAY august 15 at midnight eastern time. I’m going to read directly from a post by Joanne Milo in the CGM in the Cloud off topic group. Joanne’s been a guest of the show and leads the loop and learn group – she writes. “We have until August 15, 2022 to provide comments on FDA changes to the way CGM display and alarm systems are regulated. This has implications for remote monitoring and automated insulin delivery systems, both commercial and DIY.
We request your assistance in helping the FDA and device providers (FDA considers software for treatment of disease to be a device) understand the benefits of real-time CGM access and the risks we carry by not having ubiquitous real-time access to our diabetes device data.
We hope you will choose to spend a moment to add your voice to the #WeAreNotWaiting chorus.
They provide some text which I’ll link up in the show notes as well as the links to this post and the FDA comment portal.
https://www.regulations.gov/commenton/FDA-2018-N-1910-0047?fbclid=IwAR2WAtGl3vjTUonamNdlBtAu_pg2-xQOVy8bSqG2peLCUz2eq8R8OgLqtHQ
https://www.facebook.com/groups/CGMITCOFFTOPIC
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The T1D Exchange Registry is a research study conducted online over time, designed to foster innovation and improve the lives of people with T1D. The platform is open to both adults and children with T1D living in the U.S. Personal information remains confidential and participation is fully voluntary. Once enrolled, participants will complete annual surveys and have the opportunity to sign up for other studies on specific topics related to T1D. The registry aims to improve knowledge of T1D, accelerate the discovery and development of new treatments and technologies, and generate evidence to support policy or insurance changes that help the T1D community. By sharing opinions, experiences and data, patients can help advance meaningful T1D treatment, care and policy.
The registry is now available on the T1D Exchange website and is simple to navigate, mobile and user-friendly. For more information or to register, go to www.t1dregistry.org/stacey
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Team of 50 individuals living with type 1 diabetes will raise awareness and funds for their chronic illness

SAN MATEO, Calif., (Aug. 3, 2022) – Going the extra mile this year, global diabetes nonprofit Beyond Type 1 was named an Official Charity Partner for the 2022 TCS New York City Marathon, taking place on November 6. Beyond Type 1 will be among the 500 official charity partners providing thousands of runners the opportunity to run in the world’s most popular marathon.

This year’s Beyond Type Run team includes nearly 50 runners across the United States, Canada, Ecuador and Australia, who are raising awareness and funds for type 1 diabetes as ambassadors for Beyond Type 1, showcasing how they live beyond their diagnoses and supporting crucial efforts and programs for others affected by this condition. First-time Marathon Runner Kyle Banks, known for his tour with the Broadway cast of The Lion King, is the team captain.

“The Beyond Type Run team displays the ultimate resilience and strength as they run the marathon. If it weren’t for the team jerseys or the technology attached to their bodies, you’d never know they were living with a chronic illness,” said Beyond Type 1 CEO Deborah Dugan. “We are grateful to them for helping us raise awareness, and we thank all of our sponsors for their generous support and donations to the team.”

Since 2017, Beyond Type 1 has had roughly 150 people with type 1 diabetes run the TCS New York City Marathon through the New York Road Runners (NYRR) Official Charity Partner Program.

“The TCS New York City Marathon serves as one of the world’s largest fundraising platforms supporting hundreds of charities and philanthropic efforts,” said Christine Burke, Senior VP of Strategic Partnerships, NYRR. “We are very proud to support Beyond Type 1 and the incredible impact they have made to the diabetes community as they raise important funds to support people with diabetes.”

The NYRR Official Charity Partner Program offers an opportunity for nonprofit organizations to raise funds to support their missions and services. Participating charities can offer guaranteed entry to runners who fundraise on their behalf.

Since its inception in 2006, the TCS New York City Marathon Official Charity Partner Program has raised more than $400 million for more than 1,000 worthy nonprofit organizations across the globe. Prior to the start of the official program, the New York City Marathon had served as an outlet for individual philanthropic runners since the 1980s.

https://beyondtype1.org/beyond-type-1-nyc-marathon-2022/
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Morgan Shepard book Morgan Shepherd
So happy to announce my book “ T1D Looks Like Us! A Type 1 Diabetes Story” is now available to order! I am so excited to share this piece of my heart with you ❤️ Rose was diagnosed with Type 1 Diabetes (T1D) when she was seven years old. Now she is nine and at times feels lonely because she doesn't know any other kids with T1D. With help from her mom, Rose meets people from all over the world who also live with T1D and have their own unique stories to share!

This book is intended to spark conversations about empathy, differences, and self-compassion. Through the text children will learn not only about Type 1 Diabetes but also about the diversity of people who are living bravely with T1D. The book is perfect for newly diagnosed children, siblings, and classrooms that have a student living with T1D.
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Next week I’m talking to the folks at Patients For Affordable Drugs about the bill that passed the Senate this week. The insulin copay cap was removed, but what does it really mean for medication prices? The episode out right now is our special 500th episode where I’m interviewed by news anchor Cristina Frank, who hosts the morning show at WMTW in Maine lives with type 1.
Listen wherever you get your podcasts
That’s In the News for this week.. if you like it, please share it! Thanks for joining me! See you back here soon.

Aug 9, 2022

I started Diabetes Connections back in the summer of 2015. I'm not sure I had a number of episodes in mind when I kicked off the show, I just knew I wanted to make a podcast for and about the diabetes community. Thanks for tuning in all this time! For episode 500, I've turned hosting duties over to Cristina Frank, a TV news anchor who lives with type 1.

We talk about how the episodes come together, what's worked (and what hasn't) and what I might add to the show going forward. We also think about how the community has changed and why the highest praise I could take for this show is that it's authentic. Thanks, all!!  -Stacey

Check out Stacey's book: The World's Worst Diabetes Mom!

Join the Diabetes Connections Facebook Group!

Sign up for our newsletter here

-----

Use this link to get one free download and one free month of Audible, available to Diabetes Connections listeners!
-----

Episode Transcription Below (or coming soon!)

Please visit our Sponsors & Partners - they help make the show possible!

*Click here to learn more about OMNIPOD*

*Click here to learn more about AFREZZA*

*Click here to learn more about DEXCOM*

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